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| 品牌 | absin | CAS | 1254473-64-7 |
|---|---|---|---|
| 分子式 | C21H19Cl2N5O2 | 纯度 | 98% |
| 分子量 | 444.31 | 货号 | abs47028010 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | is a pan-FGFR inhibitor | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
LY-2874455 1254473-64-7
| 产品描述 | |
| 描述 | LY2874455 is a pan-FGFR inhibitor with IC50 of 2.8 nM, 2.6 nM, 6.4 nM, and 6 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively, and also inhibits VEGFR2 activity with IC50 of 7 nM. Phase 1. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | 100 mM in DMSO and ethanol |
| 生物活性 | |
| 靶点 | FGFR2 ,FGFR1 ,FGFR4 ,FGFR3 ,VEGFR2 |
| In vitro(体外研究) | In RT-112 cells, HUVECs, KATO-III cells, and SNU-16 cells, LY2874455 inhibits FGF/FGFR-mediated signaling activities. LY2874455 shows FGFR-dependent antiproliferative effects in KMS-11, OPM-2, SNU-16 and KATO-III cells. |
| In vivo(体内研究) | LY2874455 exhibits a potent inhibition of FGF-induced Erk phosphorylation in the heart tissues of mice with TED50 and TED90 values of 1.3 and 3.2 mg/kg, respectively. In mice bearing RT-112, OPM-2 (DSMZ), SNU-16, or NCI-H460 xenograft, LY2874455 (3 mg/kg p.o.) results in dose-dependent inhibition of the tumor growth. |
| 参考文献 | |
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| 研究领域 | |
| 研究领域 | CancerGrowth factorsFGF CancerSignal transductionProtein phosphorylationTyrosine kinasesReceptor tyrosine kinases CardiovascularAngiogenesisGrowth FactorsFGFFGF Receptors Developmental BiologyLineage specificationEctoderm NeuroscienceDevelopment NeuroscienceNeurology processNeurogenesis Signal TransductionGrowth Factors/HormonesFGF Signal TransductionProtein PhosphorylationTyrosine KinasesReceptor Tyrosine Kinases Stem CellsLineage MarkersEctoderm Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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