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| 品牌 | absin | CAS | 219766-25-3 |
|---|---|---|---|
| 分子式 | C22H21N3O3S | 纯度 | ≥98% |
| 分子量 | 407.49 | 货号 | abs47028008 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | is a selective TrkB | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
ANA-12 219766-25-3
| 产品描述 | |
| 描述 | ANA-12 is a selective TrkB antagonist with Kd of 10 nM and 12 μM for the high and low affinity sites, respectively. |
| 纯度 | ≥98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | ANA 12；ANA12 |
| 外观 | white to beige powder |
| 可溶性/溶解性 | DMSO : 14.29 mg/mL (35.07 mM) |
| 生物活性 | |
| 靶点 | TrkB |
| In vitro(体外研究) | ANA-12 binds directly and selectively to TrkB and inhibits processes downstream of TrkB without altering TrkA and TrkC functions. In nnr5 PC12-TrkB cells, ANA-12 prevents brain-derived neurotrophic factor (BDNF)-induced neurite outgrowth at concentrations as low as 10 nM. In DRG neurons, ANA-12 eliminates the effect of BDNF on increasing inward current. |
| In vivo(体内研究) | In adult C57BL6/129SveV F1s mice, ANA-12 (0.5 mg/kg, i.p.) decreases TrKB activity in the brain and reduces the anxiety- and depression-related behaviors without affecting the neuron survival. In male C57BL/6 mice, ANA-12 (0.5 mg/kg, i.p.) shows antidepressant-like effects on lipopolysaccharide-induced depression-like behavior. In male Sprague-Dawley rats, ANA-12 (3 μg/dose) blocks the effect of medial nucleus tractus solitarius (mNTS) BDNF on reducing food intake. In male wild-type mice, ANA-12 reverses ethanol intake and induces D3 receptor downregulation, but is ineffective in D3R-/- mice. In male CocSired rats, ANA-12 (0.5 mg/kg, i.p.) reverses the diminished self-administration of cocaine. |
| 研究领域 | |
| 研究领域 | CancerOncoproteins/suppressorsOncoproteinsGrowth factor receptors MetabolismPathways and ProcessesMetabolism processesCellular metabolism NeuroscienceDevelopment NeuroscienceNeurology processGrowth and DevelopmentNeurotrophins Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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