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| 品牌 | absin | CAS | 1285515-21-0 |
|---|---|---|---|
| 分子式 | C24H18FN3O2 | 纯度 | ＞98% |
| 分子量 | 399.42 | 货号 | abs47027961 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | is a potent and selective | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
GSK2578215A 1285515-21-0
| 产品描述 | |
| 描述 | GSK2578215A is a potent and selective LRRK2 kinase inhibitor with IC50 of 8.9 nM and 10.9 nM for LRRK2 (G2019S) and LRRK2 (WT), respectively. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | LRRK2-kinase inhibitor |
| 外观 | white to beige powder |
| 可溶性/溶解性 | DMSO : 50 mg/mL (125.18 mM) |
| 生物活性 | |
| 靶点 | LRRK2 (G2019S),LRRK2 (WT) |
| In vitro(体外研究) | GSK2578215A induces a dose-dependent inhibition of Ser910 and Ser935 phosphorylation in both wild-type LRRK2 and LRRK2 stably transfected into HEK293 cells, and induces similar dose-dependent Ser910 and Ser935 dephosphorylation of endogenous LRRK2 in mouse Swiss 3T3 cells. In SH-SY5Y cells, GSK2578215A impairs the autophagy flux by altering autophagosome–lysosome fusion, and induces mitophagy though induction of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling. |
| In vivo(体内研究) | In vivo, GSK2578215A (100 mg/kg i.p.) inhibits Ser910 and Ser935 phosphorylation in mouse spleen and kidney, but not in brain. |
| 参考文献 | |
| 参考文献 |
| 研究领域 | |
| 研究领域 | NeuroscienceDiseases NeuroscienceNeurology processNeurodegenerative diseaseParkinson's diseaseSynuclein Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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