Cariporide 159138-80-4

简要描述：Cariporide 159138-80-4
Cariporide (HOE-642), a potent NHE1 inhibitor, has inhibitory effects on the degranulation of human platelets

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品牌	absin	CAS	159138-80-4
分子式	C12H17N3O3S	纯度	99%
分子量	283.3467	货号	abs47027959
规格	2mg	供货周期	现货
主要用途	inhibitory effects on the degranulation	应用领域	化工,生物产业,农林牧渔,制药/生物制药,综合

Cariporide 159138-80-4

产品描述
描述	Cariporide (HOE-642), a potent NHE1 inhibitor, has inhibitory effects on the degranulation of human platelets, the formation of platelet-leukocyte-aggregates, and the activation of the GPIIb/IIIa receptor (PAC-1).
纯度	99%
储存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
可溶性/溶解性	Soluble in DMSO
生物活性
靶点	Sodium Channel
In vitro(体外研究)	Cariporide significantly suppresses markers of cell death, such as TUNEL positivity and caspase-3 cleavage, at 8 or 16 hours. Cariporide remarkably suppresses cytosolic Na+ and Ca2+ accumulation. Cariporide prevents mitochondrial membrane potential loss induced by H2+O2+. Cariporide (HOE-642) ameliorates myocardial ischemia/reperfusion injury, by the well-established reduction of cytosolic Ca2+ in cardiac myocytes through inhibition of Na+/H+ exchange. Cariporide (HOE-642), has inhibitory effects on the degranulation of human platelets, the formation of platelet–leukocyte-aggregates, and the activation of the GPIIb/IIIa receptor (PAC-1).
In vivo(体内研究)	Intravenous administration of cariporide significantly decreases brain Na+ uptake and reduces cerebral edema, brain swelling, and infarct volume.
参考文献
参考文献	1. Yang X, et al. J Surg Res. 2013 Dec;185(2):797-804. 2. Wu S, et al. Pharmacology. 2013; 91(3-4):123-30.

研究领域
研究领域	Cardiovascular Immunology CancerTumor biomarkers Drug DiscoverySmall Molecule DrugLead Compound Discovery

Cariporide 159138-80-4温馨提示：本产品仅作科研实验使用，不支持临床等研究

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