AF 353 865305-30-2

简要描述：AF 353 865305-30-2
AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist, inhibits human and rat P2X3 (pIC50= 8.0).

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AF 353 865305-30-2

产品描述
描述	AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist, inhibits human and rat P2X3 (pIC50= 8.0).
纯度	98%
储存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
别名	AF 353；Ro-4
可溶性/溶解性	DMSO : 100 mg/mL (249.87 mM; Need ultrasonic)
生物活性
靶点	P2X3
In vitro(体外研究)	AF-353 (Ro-4) is a highly potent inhibitor of α,β-meATP-evoked intracellular calcium flux in cell lines expressing recombinant rat and human P2X3 and human P2X2/3 channels. AF-353 (Ro-4) also blocks human P2X2/3 channel function with marginally reduced potency with a p50 of 7.3.
In vivo(体内研究)	AF-353 (Ro-4) does not compromise oxygen levels or cardiac function. AF-353 (Ro-4) (10 mg/kg, 20 mg/kg; i.v.; for 4-6 hours) inhibits the purinergic response in both normal and spinal cord-injured (SCI) rats. AF-353 (Ro-4) (10 mg/kg, 20 mg/kg; i.v.; for 4-6 hours) also reduces the inter-contractile interval in normal but not in SCI rats; however, the frequency of non-voiding (NVC) in SCI rats is significantly reduced.

研究领域
研究领域	CancerCancer MetabolismResponse to hypoxia MetabolismPathways and ProcessesMetabolism processesHypoxia NeuroscienceProcesses NeuroscienceNeurotransmissionReceptors / ChannelsLigand-Gated Ion ChannelsP2X Receptors Drug DiscoverySmall Molecule DrugLead Compound Discovery

AF 353 865305-30-2温馨提示：本产品仅作科研实验使用，不支持临床等研究

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