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| 品牌 | absin | CAS | 1341200-45-0 |
|---|---|---|---|
| 分子式 | C24H30ClN7O2S | 纯度 | 98% |
| 分子量 | 516.06 | 货号 | abs47027884 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | is a potent | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
TP0903 1341200-45-0
| 产品描述 | |
| 描述 | TP-0903 is a potent and selective Axl kinase inhibitor with IC50 of 27 nM. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | 10 mM in DMSO |
| 生物活性 | |
| 靶点 | Axl |
| In vitro(体外研究) | In pancreatic cancer cells (PSN-1), TP-0903 shows strong antiproliferative activity with IC50 of 6 M. TP-0903 also induces strong G2/M arrest by potently inhibiting Aurora A and B. In CLL B cells from all the patients with CLL, TP-0903 causes a dose-dependent induction of massive apoptosis by targeting phosphorylated Axl, and overcomes CLL BMSC-mediated protection of CLL B cells from apoptosis. |
| In vivo(体内研究) | In the adult rat hippocampus, the intracerebroventricular administration of SAG (2.5 nM) significantly increases the number of newly generated cells and extends survival of hippocampal cells. In mice, SAG (20 μg/g, i.p.) effectively prevents GC-induced neonatal cerebellar developmental abnormalities. |
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| 研究领域 | |
| 研究领域 | CancerCell cycleKinases/phosphatasesOther CancerOncoproteins/suppressorsOncoproteinsSignal transducers CancerSignal transductionOther Cell CycleKinases/PhosphatasesOther NeuroscienceProcesses Signal TransductionProtein PhosphorylationTyrosine KinasesReceptor Tyrosine Kinases Tags & Cell MarkersCell Type MarkersTumor Associated Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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