Hydroxy Camptothecine 64439-81-2

简要描述：Hydroxy Camptothecine 64439-81-2
An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata.

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详细介绍

品牌	absin	CAS	64439-81-2
分子式	C20H16N2O5	纯度	99%
分子量	364.35	货号	abs47027739
规格	5mg	供货周期	现货
主要用途	This compound selectively inhibits the n	应用领域	化工,生物产业,农林牧渔,制药/生物制药,综合

Hydroxy Camptothecine 64439-81-2

产品描述
描述	An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA topoisomerase, type I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
纯度	99%
储存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
可溶性/溶解性	Soluble in DMSO
生物活性
靶点	DNA topoisomerase I
In vitro(体外研究)	10-HCPT has an inhibitory effect on phosphorylation of histone H1 and H3 in murine hepatoma cells and also exhibits a differentiation inducing effect in human HepG2 cells. 10-HCPT inhibits the cell growth, reduces the cell viability and disturbs the cell cycle distribution of human colon cancer cell line Colo 205. It induces cell cycle arrest in the G2/M phase.
In vivo(体内研究)	10-HCPT can be safely orally administered and, alternatively, a low-dose long-term treatment. Prolonged elimination of HCPT in vivo may have a significant impact on its therapeutic effects. HCPT is metabolized to its carboxylate form and glucuronides. Dose-dependent toxicity is observed with i.v. administration of HCPT.
参考文献
参考文献	1. Zhang S, et al. Anticancer Drugs. 2014 Jul;25(6):614-23. 2. Chen ZH, et al. PLoS One. 2013; 8(1):e53291. 3. Tan H, et al. Bioorg Med Chem. 2015 Jan 1; 23(1):118-25.

研究领域
研究领域	CancerDrug resistanceTopoisomerases EpigeneticsDNA / RNADNA SynthesisTopoisomerases Drug DiscoverySmall Molecule DrugLead Compound Discovery

Hydroxy Camptothecine 64439-81-2温馨提示：本产品仅作科研实验使用，不支持临床等研究

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