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| 品牌 | absin | CAS | 81098-60-4 |
|---|---|---|---|
| 分子式 | C23H29ClFN3O4 | 纯度 | ＞98% |
| 分子量 | 465.95 | 货号 | abs47027605 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | is a serotonin type 4 (5-HT4) receptor a | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Cisapride 81098-60-4
| 产品描述 | |
| 描述 | Cisapride is a serotonin type 4 (5-HT4) receptor agonists are potent prokinetic agents that act on serotonin receptors in the intestine and promote intestinal peristalsis, increase gastric emptying and decrease esophageal reflux. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 西sha必利；R 51619；(±)-Cisaprid |
| 外观 | 白色固体 |
| 可溶性/溶解性 | 10 mM in DMSO |
| 生物活性 | |
| 靶点 | hERG channel ,5-HT4 receptor |
| In vitro(体外研究) | Cisapride is a 5-HT4 receptor agonist, also a hERG blockers. It is widely used for the treatment of gastrointestinal motility dysfunctions, such as gastroesophageal reflux disorder (GERD), chronic intestinal pseudo-obstruction, and slow-transit constipation gastroparesis. Cisapride works by promoting gastrointestinal motility through stimulating the release of intestinal acetylcholine from muscarinic receptors. Cisapride inhibits Kv 4.3 channels that are stably expressed in Chinese hamster ovary (CEO) cells as well as the current in L-type Ca2+ channels of ventricular myocytes. Cisapride inhibited Kv channel current in a concentration-dependent manner independent of its own function as a selective serotonin 5-HT4-receptor agonist. |
| 参考文献 | |
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| 研究领域 | |
| 研究领域 | MetabolismTypes of diseaseObesity NeuroscienceProcesses NeuroscienceNeurology processMetabolism NeuroscienceNeurotransmissionReceptors / ChannelsGPCRSerotonin Receptors Signal TransductionSignaling PathwayG Protein SignalingGPCR Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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