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| 品牌 | absin | CAS | 19237-84-4 |
|---|---|---|---|
| 分子式 | C19H22ClN5O4 | 纯度 | ＞98% |
| 分子量 | 419.86 | 货号 | abs47027465 |
| 规格 | 50mg | 供货周期 | 现货 |
| 主要用途 | used to treat high blood pressure | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Prazosin hydrochloride 19237-84-4
| 产品描述 | |
| 描述 | Prazosin is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | yan酸哌唑嗪；Prazosin HCl |
| 外观 | 白色或类白色结晶性粉末 |
| 可溶性/溶解性 | DMSO : 25 mM Ethanol : 5 mM |
| 生物活性 | |
| 靶点 | alpha-adrenergic receptor |
| In vitro(体外研究) | Prazosin leads to a significant increase in VEGF concentration in endothelial cells and angiogenesis only if eNOS is present. Prazosin binds to the α1-adrenergic receptors that are present on smooth muscle cells surrounding all larger blood vessels. Prazosin (0.1 nM) blocks the increases in perfusion pressure caused by electrical stimulation of the perimesenteric nerves but does not significantly reduce the vasomotor effect of exogenous noradrenaline. |
| In vivo(体内研究) | Prazosin application leads to the expansion of the capillary system by modulation of the hemodynamic environment (flow rate, shear stress) in skeletal muscle. Prazosin induces angiogenesis in extensor digitorum longus (EDL) muscles of C57BL/6 mice but not eNOS-knockout mice. Prazosin (0.5-2.0 mg/kg) blocks Yohimbine-induced reinstatement of food and alcohol seeking, as well as footshock-induced reinstatement of alcohol seeking in rats. Prazosin (0.2mg kg(-1) s.c.) causes an enhancement of a suppression of conditioned avoidance response in the presence of the dopamine D2 receptor antagonist raclopride (0.05-0.20 mg/kg s.c.) in rats. Prazosin administration alone (1 mg/kg, s.c.) only slightly reduces horizontal activity during an initial 10 min measurement period, although it consistently reduces rearing in freely moving rats. Prazosin effectively suppresses the locomotor stimulation caused by either dose of MK-801 throughout the whole observation period in freely moving rats. |
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| 研究领域 | |
| 研究领域 | Cardiovascular CancerTumor biomarkers NeuroscienceEndocrine system Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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