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| 品牌 | absin | CAS | 50-22-6 |
|---|---|---|---|
| 分子式 | C21H30O4 | 纯度 | ＞98% |
| 分子量 | 346.46 | 货号 | abs47027406 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | is a sensitive inhibitor of monoamine t | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Corticosterone 50-22-6
| 产品描述 | |
| 描述 | Corticosterone is a sensitive inhibitor of monoamine transport. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 肾上腺酮；皮质酮；17-Deoxycortisol； 11β,21-Dihydroxyprogesterone；Kendall's compound B |
| 外观 | 白色或类白色粉末 |
| 可溶性/溶解性 | DMSO : 34.7 mg/mL (100 mM) Ethanol : 3.5 mg/mL (10 mM) |
| 生物活性 | |
| 靶点 | Glucocorticoid receptor |
| In vitro(体外研究) | Corticosterone, via SGK phosphorylation of GDI at Ser-213, increases the formation of GDI-Rab4 complex, facilitating the functional cycle of Rab4 and Rab4-mediated recycling of AMPARs to the synaptic membrane. It enhances AMPAR-mediated miniature excitatory postsynaptic current (mEPSC) amplitude and surface expression of GluR1 and GluR2 subunits in hippocampal neurons, increases the surface mobility and synaptic content of AMPAR GluR2 subunits, and enhances L-type calcium currents in CA1 pyramidal neurons. Corticosterone operates through mineralocorticoid receptors and glucocorticoid receptors, both of which belong to the family of nuclear receptors that bind to response elements in the DNA, thus modifying the activity of responsive genes. |
| In vivo(体内研究) | Corticosterone plays an important role in regulating neuronal functions of the limbic system. After stress, the level of stress hormones such as corticosterone is markedly increased. Corticosterone exerts a time- and region-specific action on cellular physiology of limbic neurons. |
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| 研究领域 | |
| 研究领域 | CancerSignal transductionNuclear signalingNuclear hormone receptorsOther EpigeneticsNuclear Signaling PathwaysNuclear ReceptorsCorticoid NeuroscienceProcesses Signal TransductionSignaling PathwayNuclear SignalingNuclear Hormone ReceptorsCorticoid Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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