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| 品牌 | absin | CAS | 74610-55-2 |
|---|---|---|---|
| 分子式 | C46H77NO17.C4H6O6 | 纯度 | 98% |
| 分子量 | 1066.19 | 货号 | abs47027351 |
| 规格 | 50mg | 供货周期 | 现货 |
| 主要用途 | is a macrolide antibiotic | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Tylosin tartrate 74610-55-2
| 产品描述 | |
| 描述 | Tylosin tartrate is a macrolide antibiotic approved for the control of mycoplasmosis in poultry. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 酒石酸泰乐菌素,酒石酸泰洛星 |
| 外观 | 白色或类白色粉末 |
| 可溶性/溶解性 | DMSO : 276 mg/mL (262.3 mM) Ethanol : 179 mg/mL (170.1 mM) Water : 183 mg/mL (173.9 mM) |
| 生物活性 | |
| In vitro(体外研究) | Tylosin tartrate (25 mg/L) significantly inhibits methane production relative to unamended controls, thus indicating that Tylosin tartrate at concentrations commonly found in swine lagoons can negatively impact anaerobic metabolism. Tylosin disappearance follows a biphasic pattern, where rapid initial loss is followed by a slow removal phase. The 90% disappearance times for tylosin, relomycin (tylosin D), and desmycosin (tylosin B) in anaerobically incubated slurries are 30 to 130 hours, and aerating the slurries reduced the 90% disappearance times to between 12 and 26 hours. Tylosin tartrate is stable for at least one month when stored in Milli-Q water at pH 5.7 to 6.7 at 22 ℃. |
| In vivo(体内研究) | Tylosin increases splenocyte proliferation and splenocyte conditioned medium (CM) proliferative activity above control levels from whole splenocyte cultures in chickens. Tylosin also increases antitumor activity of splenocytes in chickens. Tylosin tartrate (50 mg/kg) administered orally twice daily for 10 days, beginning 14 days after intranasal infection, significantly reduces the incidence and severity of macroscopical pneumonic lung lesions in neonatal piglets. After tylosin tartrate administered intravenously (i.v.) at 10 mg/kg in camels, serum tylosin concentrations in the water-deprived camels are significantly higher, rate of drug elimination is slower, the volume of distribution is significantly smaller, and total body clearance is significantly slower than in the normal camels. On the other hand, serum tylosin concentrations are lower in the water deprived camels and the mean absorption time is significantly shorter in camels treat with tylosin tartrate (20 mg/kg i.m.). |
| 参考文献 | |
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| 研究领域 | |
| 研究领域 | Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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