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| 品牌 | absin | CAS | 69304-47-8 |
|---|---|---|---|
| 分子式 | C11H13BrN2O5 | 纯度 | 99% |
| 分子量 | 333.14 | 货号 | abs47027261 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | used in the treatment of herpes zoster | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Brivudine 69304-47-8
| 产品描述 | |
| 描述 | Brivudine is an antiviral drug used in the treatment of herpes zoster. |
| 纯度 | 99% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 溴fu定；溴比夫定； Bromovinyldeoxyuridine；BVDU |
| 外观 | 白色至淡黄色结晶性粉末 |
| 可溶性/溶解性 | DMSO : ≥330 mg/mL |
| 生物活性 | |
| 靶点 | CMV |
| In vitro(体外研究) | Brivudine is an analog of thymidine, and is incorporated into the viral DNA. It blocks the action of DNA polymerases, thus inhibiting viral replication. It has a stronger antiviral effect against the varicella-zoster virus compared with reference compounds such as aciclovir or penciclovir. It has high, selective activity against varicella zoster virus (VZV), inhibiting VZV replication, possibly through competitive inhibition of viral DNA polymerase, or by acting as an alternative substrate to deoxythymidine triphosphate, causing viral DNA strand breakage. |
| In vivo(体内研究) | At a dose of 125 mg once daily, brivudine has proved to be superior to aciclovir with respect to reducing the period of new blister production, and has shortened the duration of post-herpetic neuralgia. |
| 参考文献 | |
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| 研究领域 | |
| 研究领域 | MetabolismTypes of disease Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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