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| 品牌 | absin | CAS | 83915-83-7 |
|---|---|---|---|
| 分子式 | C21H35N3O7 | 纯度 | 99% |
| 分子量 | 441.52 | 货号 | abs4702725 |
| 规格 | 500mg | 供货周期 | 现货 |
| 主要用途 | used in treatment of hypertension | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Lisinopril dihydrate 83915-83-7
| 产品描述 | |
| 描述 | Lisinopril Dihydrate is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks. |
| 纯度 | 99% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 赖诺pu利二水合物 |
| 可溶性/溶解性 | H2O : 33.33 mg/mL (75.49 mM; Need ultrasonic) DMSO : 1 mg/mL (2.26 mM; Need ultrasonic) |
| 生物活性 | |
| 靶点 | ACE |
| In vitro(体外研究) | Lisinopril significantly reduces left ventricular (LV) end-diastolic pressure (EDP), pulmonary capillary wedge pressure (PCWP) and end-diastolic stress, addition of atenolol to Lisinopril further reduces EDP and PCWP. Lisinopril is a structural homologue of enalaprilat, differing only in the second amino acid side chain. Lisinopril inhibits Angiotensin-converting enzyme (ACE) in vitro, as well as after parenteral and oral administration to humans; its oral bioavailability is only 25-29%, but it has a longer duration of action than enalapril. |
| In vivo(体内研究) | Lisinopril treated SHR rats has significantly raised total cholesterol levels compared to untreated spontaneously hypertensive rats (SHR) rats (+27%), but not compared to lisinopril treated Wistar Kyoto rats (WKY) rats. Lisinopril is a long-acting angiotensin-converting enzyme inhibitor which blocks the renin-angiotensin system (RAS) and reduces systemic blood pressure in rats. Lisinopril reduces the hydroxyproline level and inhibits accumulation of collagens in the pulmonary tissue of the treatment group (paraquat + lisinopril) and per-treatment group (lisinopril + paraquat) in rats. Lisinopril results in preserved ultrafiltration volume (UF), glucose reabsorption (D 1 /D 0 glucose) and peritoneal thickness in rats. Lisinopril (0.2 mg/kg twice a day for 10 days) protects the cell membrane integrity and lessens free radical-induced oxidant stress in guinea pig hearts. |
| 研究领域 | |
| 研究领域 | NeuroscienceEndocrine system Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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