I-BET151 1300031-49-5 I-BET151 (GSK1210151A) is a novel selective BET inhibitor for BRD2, BRD3 and BRD4 with IC50 of 0.5 μM, 0.25 μM, and 0.79 μM, respectively.

Omecamtiv mecarbil (CK-1827452) 873697-71-3 Omecamtivmecarbil (CK-1827452) is a specific cardiac myosinactivator and a clinical drug for left ventricular systolic heart failure.

JNJ26854165 881202-45-5 JNJ-26854165 (Serdemetan) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells

TAK-632 1228591-30-7 TAK-632 is a selective pan-RAF kinase inhibitor with IC50 values of 2.4/1.4 nM for BRAF V600E/c-RAF; 60 fold selectivity over VEGFR.

SC-514 (GK 01140) 354812-17-2 SC-514 (GK 01140), a small molecule, is a selective inhibitor of IKK-2; does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.

AGI5198 1355326-35-0 AGI-5198 is the first highly potent and selective inhibitor of IDH1 R132H/R132C mutants with IC50 of 0.07 μM/0.16 μM.

ABT-199 1257044-40-8 ABT-199 is a Bcl-2-selective inhibitor with Ki of 0.01 nM in cell-free assays, 4800-fold more selective versus Bcl-xL and Bcl-w, and no activity to Mcl-1. Phase 3.

TAE-226 761437-28-9 TAE226 (NVP-TAE226) is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2, ~10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met.