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| 品牌 | absin | CAS | 88150-42-9 |
|---|---|---|---|
| 分子式 | C26H31ClN2O8S | 纯度 | 99% |
| 分子量 | 567.05 | 货号 | abs47027674 |
| 规格 | 500mg | 供货周期 | 现货 |
| 主要用途 | is a long-acting calcium channel blocker | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Amlodipine 88150-42-9
| 产品描述 | |
| 描述 | Amlodipine is a long-acting calcium channel blocker. Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the movement of calcium ions into vascular smooth muscle cells and cardiac muscle cells. |
| 纯度 | 99% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 氨氯di平 |
| 外观 | 白色或类白色粉末 |
| 可溶性/溶解性 | Soluble in water |
| 生物活性 | |
| 靶点 | Calcium channel |
| In vitro(体外研究) | Amlodipine causes a dose-dependent increase in nitrite production. Amlodipine also increases nitrite production in large coronary arteries and in aorta. Amlodipine is attributed to distinct membrane physico-chemical interactions. Amlodipine contributes to distinct membrane biophysical interactions that lead to potent lipid antioxidant effects, independent of calcium channel modulation. Amlodipine increases plaque smooth muscle cell content (P Amlodipine attenuates intracellular neuronal Ca2+ increases elicited by KCl depolarization but does not affect Ca2+ changes triggered by N-methyl-D-aspartate receptor activation. Amlodipine also inhibits free radical-induced damage to lipid constituents of the membrane in a dose-dependent manner, independent of Ca2+ channel modulation. |
| In vivo(体内研究) | Amlodipine results in regression of cardiovascular hypertrophy and amelioration of endothelial dysfunction in spontaneously hypertensive rats. Amlodipine significantly reduces aortic hypertrophy, endothelial dysfunction, LOX-1 expression, aortic O(2)(-) and ONOO(-) production, and plasma free 8-F(2)alpha-isoprostane levels in Ang II-infused rats. Amlodipine has antihypertensive and antioxidant activity in vivo, which effectively inhibits many of the oxidative stress-dependent mechanisms involved in Ang II-mediated cardiovascular injury. |
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| 研究领域 | |
| 研究领域 | Cardiovascular CancerCancer Metabolism CancerTumor biomarkers Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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