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Rabbit anti-NLRP3 Polyclonal Antibody

简要描述:Rabbit anti-NLRP3 Polyclonal Antibody Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

  • 产品型号:abs151406
  • 厂商性质:生产厂家
  • 更新时间:2021-12-19
  • 访  问  量:52

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详细介绍

品牌自营品牌供货周期现货
应用领域化工,生物产业,能源
概述
别名
NLRP3抗体;NLRP3;AGTAVPRL;AII;AVP;C1orf7;CIAS1;CLR1.1;FCAS;FCAS1;FCU;MWS;NALP3;PYPAF1
宿主
Rabbit
反应种属
Human,Mouse,Rat
应用
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
免疫原
A synthetic peptide of human NLRP3 (NP_001120934.1).
性能
纯化方法
Affinity purification
类型
Polyclonal Antibody
同种型
IgG
存储溶液
Rabbit anti-NLRP3 Polyclonal AntibodyStore at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
靶标
背景说明
Rabbit anti-NLRP3 Polyclonal AntibodyThis gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.
UniProt
Q96P20
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