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霍乱毒素B亚单位

简要描述:霍乱毒素B亚单位2–8 °C, The product, as supplied, is stable 2 years when stored properly. Solutions are stable for at least 3 months when stored at 2–8 °C.

  • 产品型号:abs80001
  • 厂商性质:生产厂家
  • 更新时间:2021-12-18
  • 访  问  量:41

详细介绍

品牌absin供货周期现货
应用领域生物产业
产品描述
描述

Cholera toxin (CTB,霍乱毒素B亚基)belongs to the AB5 –subunit family oftoxins.The native hexameric protein has a molecular mass of ~85 kDa and contains two subunits. It consists of a single A subunit (~27.2 kDa), responsible for the ADP-ribosylation activity, and five B subunits(~11.6 kDa each), which are arranged as a pentameric ring with an apparent 5-fold symmetry and are associated with the cell surface receptor binding and subsequent internalization (transmembrane transport)of the enzymatic component.

纯度
霍乱毒素B亚单位 ≥95%
储存/保存方法
2–8 °C, The product, as supplied, is stable 2 years when stored properly. Solutions are stable for at least 3 months when stored at 2–8 °C. DO NOT FREEZE.
技术指标

Format:Recombinant
Source:E.coli
Sodium azide:Not add.

产品用途
Cholera toxin and its purified A subunit are frequently used for the study of signal transduction mechanisms.In addition,cholera toxin acts as an adjuvant through the stimulation of B lymphocytes. The cholera toxin B subunit alone is used for track tracing in neurological research, taking advantage of GM1 ganglioside binding and retrograde transport.Tissue culture cells treated with cholera toxin are not killed and tissues of animals do not become necrotic.
注意事项
The B subunit is non-toxic to cells and possesses no intrinsic adenylate cyclase activity. The cholera toxin B subunit (CTB) attaches to cells by binding to ganglioside GM1.8 CTB has been shown to be a good label for microglial cells (due to the enrichment of ganglioside GM1 on their cell surface), but not for oligodendrocytes or astrocytes. The B subunit has been reported to be an excellent tracer for the study of axonal transport using immunohistochemical methods. Recently it has been widely used as a marker of membrane lipid rafts, which are membrane microdomains enriched with cholestrol and sphingolipids. These lipid rafts have an important role in cell signaling and protein trafficking.
基本信息
别名
霍乱毒素B亚基、CHOLERA TOXIN B SUBUNIT、CTB、 Cholera Toxin B subunit、CTxB、Choleragenoid
外观
霍乱毒素B亚单位 powder
可溶性/溶解性
H2O: soluble 1mg/mL
参考文献
参考文献
1. Nedelkoska, L., and Benjamins, J.A., Binding of cholera toxin B subunit: a surface marker for murine microglia but not oligodendrocytes or astrocytes. J. Neurosci. Res., 53, 605-612 (1998).
2. Janes, P.W., et al., Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor. J. Cell Biol., 147, 447-461 (1999).
温馨提示:本产品仅作科研实验使用,不支持临床等研究

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