Recombinant human PDCD1/PD1 protein aa1-165 was produced in mammalian cells with C-terminal DYKDDDDK tag. The theoretical molecular weight of PDCD1/PD1a is 19.9 kDa.Purified PDCD1/PD1 protein is near the position of 34 kDa on SDS-PAGE gel under reduced condition.
PDCD1/PD1 protein is purified by proprietary chromatographic techniques.
Entrez Gene summary for PDCD1/PD1:
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis.
UniProtKB/Swiss-Prot: PDCD1/PD1_HUMAN, Q15116
Function: Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors.
形态 Protein is supplied in 50 mM Tris, 150 mM NaCl, 10% Glycerol, 150 ug/ml Flag peptide, pH 7.5.
来源 Mammalian cells, HEK293.
保存方法 Clear solution, frozen.Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.